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Bufalin
CAS No. 465-21-4
Bufalin( NSC 89595 )
Catalog No. M14561 CAS No. 465-21-4
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 120 | In Stock |
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| 50MG | 177 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBufalin
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NoteResearch use only, not for human use.
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Brief DescriptionBufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
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DescriptionBufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
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In VitroCell Viability Assay Cell Line:NCI-H460 cells Concentration:0, 1, 2, 4 μM Incubation Time:48 hours Result:Decreased viability of NCI-H460 cells in a dose-dependent manner.
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In VivoAnimal Model:Forty male athymic BALB/c nu/nu mice (6-8 weeks old)Dosage:0.1, 0.2, or 0.4 mg/kg Administration:I.P. every day until 14 days Result:Dose-dependently suppressed tumor growth.
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SynonymsNSC 89595
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorNa+/K+-ATPase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number465-21-4
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Formula Weight386.52
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Molecular FormulaC24H34O4
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILES5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
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Chemical Name5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.
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