Bufalin ( NSC 89595 )

Catalog No. M14561 CAS No. 465-21-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Bufalin
Note

Research use only, not for human use.
Brief Description

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
Description

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
Synonyms

NSC 89595
Pathway

Endocrinology/Hormones
Target

ATPase
Recptor

Na+/K+-ATPase
Research Area

Cancer
Indication

——

CAS Number

465-21-4
Formula Weight

386.52
Molecular Formula

C24H34O4
Purity

>98%(HPLC)
Solubility

DMSO: 10 mM
SMILES

5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
Chemical Name

5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one

1.Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.

Calculator

molnova catalog