Bufalin

CAS No. 465-21-4

Bufalin( NSC 89595 )

Catalog No. M14561 CAS No. 465-21-4

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bufalin
  • Note
    Research use only, not for human use.
  • Brief Description
    Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
  • Description
    Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
  • In Vitro
    Cell Viability Assay Cell Line:NCI-H460 cells Concentration:0, 1, 2, 4 μM Incubation Time:48 hours Result:Decreased viability of NCI-H460 cells in a dose-dependent manner.
  • In Vivo
    Animal Model:Forty male athymic BALB/c nu/nu mice (6-8 weeks old)Dosage:0.1, 0.2, or 0.4 mg/kg Administration:I.P. every day until 14 days Result:Dose-dependently suppressed tumor growth.
  • Synonyms
    NSC 89595
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    Na+/K+-ATPase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    465-21-4
  • Formula Weight
    386.52
  • Molecular Formula
    C24H34O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
  • Chemical Name
    5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.
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