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Broflanilide
CAS No. 1207727-04-5
Broflanilide( —— )
Catalog No. M26075 CAS No. 1207727-04-5
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 66 | Get Quote |
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| 5MG | 110 | Get Quote |
|
| 10MG | 178 | Get Quote |
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| 25MG | 390 | Get Quote |
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| 50MG | 593 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBroflanilide
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NoteResearch use only, not for human use.
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Brief DescriptionBroflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.
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DescriptionBroflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.(In Vitro):Broflanilide is an insecticide and metabolized to desmethyl-broflanilide. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 and 0.149 μM respectively.
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In VitroBroflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM).
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptormicrotubule-associated protein 2
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Research Area——
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Indication——
Chemical Information
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CAS Number1207727-04-5
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Formula Weight663.285
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Molecular FormulaC25H14BrF11N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (376.91 mM)
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SMILESCN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(cc2C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)c1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fontaine-Lenoir V, et, al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4711-6.
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