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Briciclib

CAS No. 865783-99-9

Briciclib( ON 014185 )

Catalog No. M19193 CAS No. 865783-99-9

Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Briciclib
  • Note
    Research use only, not for human use.
  • Brief Description
    Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
  • Description
    Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.(In Vitro):Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
  • In Vitro
    Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
  • In Vivo
    ——
  • Synonyms
    ON 014185
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Cyclin D1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    865783-99-9
  • Formula Weight
    474.42
  • Molecular Formula
    C19H23O10PS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 31 mg/mL; 65.34 mM
  • SMILES
    c1(cc(c(c(c1)OC)/C=C/S(=O)(=O)Cc1ccc(c(c1)OP(=O)(O)O)OC)OC)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neel Jasani, et al. DOI: 10.1158/1538-7445.
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