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STK899704
CAS No. 1578247-29-6
STK899704( STK-899704 | STK 899704 )
Catalog No. M12256 CAS No. 1578247-29-6
A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSTK899704
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NoteResearch use only, not for human use.
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Brief DescriptionA novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM.
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DescriptionA novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM; suppresses the growth of HeLa cells with IC50 of 350 nM, prevents the polymerization of purified tubulin in vitro and also depolymerizes microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and Plk1 and apoptosis; shows anticancer activity in vivo.
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In Vitro——
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In Vivo——
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SynonymsSTK-899704 | STK 899704
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorMicrotubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number1578247-29-6
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Formula Weight453.498
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Molecular FormulaC27H23N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCCOC(=O)CN1C(=C(C2=CC=CC=C21)C=NNC(=O)C3=CC4=C(O3)C=CC5=CC=CC=C54)C
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Chemical NameEthyl (E)-2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sakchaisri K, et al. PLoS One. 2017 Mar 15;12(3):e0173311.
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