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Benzonatate

CAS No. 104-31-4

Benzonatate( —— )

Catalog No. M22185 CAS No. 104-31-4

Benzonatate is an antagonist of sodium channel protein.Na(+) currents are inhibited most potently by a benzonatate fraction containing the 9-ethoxy component.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Benzonatate
  • Note
    Research use only, not for human use.
  • Brief Description
    Benzonatate is an antagonist of sodium channel protein.Na(+) currents are inhibited most potently by a benzonatate fraction containing the 9-ethoxy component.?
  • Description
    Benzonatate is an antagonist of sodium channel protein.Na(+) currents are inhibited most potently by a benzonatate fraction containing the 9-ethoxy component.?Detectable effects of benzonatate occur at concentrations as low as 0.3 μM, which has been reported in humans. benzonatate has local anesthetic-like effects on voltage-gated sodium channels, including Nav1.7, which is a possible mechanism for cough suppression by the drug.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    sodium channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    104-31-4
  • Formula Weight
    603.75
  • Molecular Formula
    C30H53NO11
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (165.63 mM)
  • SMILES
    CCCCNc1ccc(cc1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Evans M S , Maglinger G B , Fletcher A M , et al. Benzonatate inhibition of voltage-gated sodium currents[J]. Neuropharmacology, 2016, 101:179.
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