A-317567

Research use only, not for human use.

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.Pain Discontinued

A317567

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

Pain

371217-32-2

397.57

C27H31N3

>98% (HPLC)

10 mM in DMSO

N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N

6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide

(-20℃)

With Ice Pack

≥ 2 years