Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - A-317567

A-317567

CAS No. 371217-32-2

A-317567( A317567 )

Catalog No. M14278 CAS No. 371217-32-2

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 336 Get Quote
50MG 1899 Get Quote
100MG 2835 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    A-317567
  • Note
    Research use only, not for human use.
  • Brief Description
    A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.
  • Description
    A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.Pain Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Sprague-Dawley rats (230-350 g) injected with Complete Freund’s Adjuvant- (CFA-) induced thermal hyperalgesia.Dosage:1-100 μmol/kg Administration:i.p; once Result:Showed dose-dependent analgesic effects.
  • Synonyms
    A317567
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    371217-32-2
  • Formula Weight
    397.566
  • Molecular Formula
    C27H31N3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N
  • Chemical Name
    6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dubé GR, et al. Pain. 2005 Sep;117(1-2):88-96. 2. Hayes SG, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1720-5. 3. Dwyer JM, et al. Psychopharmacology (Berl). 2009 Mar;203(1):41-52. 4. Kuduk SD, et al. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • VX-150

    VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).

  • Mepivacaine B

    Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals.

  • GNE-131

    GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).

Sign In Join Free