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A-317567

CAS No. 371217-32-2

A-317567( A317567 )

Catalog No. M14278 CAS No. 371217-32-2

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    A-317567
  • Note
    Research use only, not for human use.
  • Brief Description
    A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.
  • Description
    A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.Pain Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Sprague-Dawley rats (230-350 g) injected with Complete Freund’s Adjuvant- (CFA-) induced thermal hyperalgesia.Dosage:1-100 μmol/kg Administration:i.p; once Result:Showed dose-dependent analgesic effects.
  • Synonyms
    A317567
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    371217-32-2
  • Formula Weight
    397.566
  • Molecular Formula
    C27H31N3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N
  • Chemical Name
    6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dubé GR, et al. Pain. 2005 Sep;117(1-2):88-96. 2. Hayes SG, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1720-5. 3. Dwyer JM, et al. Psychopharmacology (Berl). 2009 Mar;203(1):41-52. 4. Kuduk SD, et al. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24.
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