BTC-8 ( BTC 8;BTC8 )

Catalog No. M17097 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BTC-8
Note

Research use only, not for human use.
Brief Description

A derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.
Description

A derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM; inhibits GBM cell proliferation, arrests the cell cycle, and induces apoptosis through the induction of mitochondrial membrane permeabilization; also blocks proliferation and self-renewal of GSCs and induces their apoptosis; sensitizes both GBM cells and GSCs to the alkylating agent Temozolomide.
Synonyms

BTC 8;BTC8
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

--
Formula Weight

457.53
Molecular Formula

C26H27N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N(C2=CC=C(C3=CC=C(N(C)C)C=C3)C(O)=C2)N=C(C)/C1=N\NC4=CC=CC=C4OCC
Chemical Name

(E)-2-(4'-(dimethylamino)-2-hydroxy-[1,1'-biphenyl]-4-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.
2. Stornaiuolo M, et al. J Med Chem. 2015 Mar 12;58(5):2135-48.

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