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BTC-8
CAS No. ——
BTC-8( BTC 8 | BTC8 )
Catalog No. M17097 CAS No. ——
A derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBTC-8
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NoteResearch use only, not for human use.
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Brief DescriptionA derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.
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DescriptionA derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM; inhibits GBM cell proliferation, arrests the cell cycle, and induces apoptosis through the induction of mitochondrial membrane permeabilization; also blocks proliferation and self-renewal of GSCs and induces their apoptosis; sensitizes both GBM cells and GSCs to the alkylating agent Temozolomide.
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In Vitro——
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In Vivo——
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SynonymsBTC 8 | BTC8
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight457.534
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Molecular FormulaC26H27N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=CC=C(C3=CC=C(N(C)C)C=C3)C(O)=C2)N=C(C)/C1=N\NC4=CC=CC=C4OCC
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Chemical Name(E)-2-(4'-(dimethylamino)-2-hydroxy-[1,1'-biphenyl]-4-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.
2. Stornaiuolo M, et al. J Med Chem. 2015 Mar 12;58(5):2135-48.
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