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HA14-1
CAS No. 65673-63-4
HA14-1 ( HA-14-1;HA 14-1 )
Catalog No. M15498 CAS No. 65673-63-4
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 35 | In Stock |
|
| 25MG | 56 | In Stock |
|
| 50MG | 80 | In Stock |
|
| 100MG | 115 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHA14-1
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NoteResearch use only, not for human use.
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Brief DescriptionHA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM.
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DescriptionHA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells; effectively induces apoptosis of HL-60 cells overexpressing Bcl-2 protein associated with the decrease in mitochondrial membrane potential and activation of caspase-9 followed by caspase-3; strongly induces the death of NIH 3T3 (Apaf-1(+/+)) cells.
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SynonymsHA-14-1;HA 14-1
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number65673-63-4
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Formula Weight409.23
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Molecular FormulaC17H17BrN2O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=C(N)OC2=C(C=C(Br)C=C2)[C@H]1[C@H](C#N)C(OCC)=O)OCC
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Chemical Name4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-.alpha.-cyano-3-(ethoxycarbonyl)-, ethyl ester, (.alpha.R,4R)-rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang JL, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9.
2. Milella M, et al. Blood. 2002 May 1;99(9):3461-4.
3. Chen J, et al. Mol Cancer Ther. 2002 Oct;1(12):961-7.
4. Lickliter JD, et al. Leukemia. 2003 Nov;17(11):2074-80.
2. Milella M, et al. Blood. 2002 May 1;99(9):3461-4.
3. Chen J, et al. Mol Cancer Ther. 2002 Oct;1(12):961-7.
4. Lickliter JD, et al. Leukemia. 2003 Nov;17(11):2074-80.
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