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BI-3812

CAS No. 2166387-64-8

BI-3812 ( BI3812;BI 3812 )

Catalog No. M13458 CAS No. 2166387-64-8

A highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 237 Get Quote
10MG 402 Get Quote
25MG 665 Get Quote
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Biological Information

  • Product Name
    BI-3812
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
  • Description
    A highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 40 nM in vitro.
  • Synonyms
    BI3812;BI 3812
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2166387-64-8
  • Formula Weight
    558.04
  • Molecular Formula
    C26H32ClN7O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 20.83 mg/mL 37.33 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1CCN(C2=NC=C(Cl)C(NC3=CC4=C(N(C)C(C(OCC(NC)=O)=C4)=O)C(OC)=C3)=N2)CC1)N(C)C
  • Chemical Name
    1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.
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