BTB06584

CAS No. 219793-45-0

BTB06584( BTB )

Catalog No. M13505 CAS No. 219793-45-0

BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 27 In Stock
5MG 43 In Stock
10MG 60 In Stock
25MG 79 In Stock
50MG 113 In Stock
100MG 203 In Stock
200MG 313 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BTB06584
  • Note
    Research use only, not for human use.
  • Brief Description
    BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
  • Description
    BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.
  • In Vitro
    In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced. BTB06584 efficiency is increased by IF1 overexpression and reduced by silencing the protein.
  • In Vivo
    BTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish.
  • Synonyms
    BTB
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ATPase| Acetohydroxyacid synthase
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    219793-45-0
  • Formula Weight
    417.82
  • Molecular Formula
    C19H12ClNO6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 84 mg/mL (201.04 mM)
  • SMILES
    O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O
  • Chemical Name
    2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang D, et al. J Chem Inf Model. 2013 Feb 25;53(2):343-53.
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