Cart
sales@molnova.com
BSJ-03-123
CAS No. 2361493-16-3
BSJ-03-123( —— )
Catalog No. M21744 CAS No. 2361493-16-3
BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 110 | Get Quote |
|
| 5MG | 177 | Get Quote |
|
| 10MG | 259 | Get Quote |
|
| 25MG | 410 | Get Quote |
|
| 50MG | 560 | Get Quote |
|
| 100MG | 799 | Get Quote |
|
| 500MG | 1611 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBSJ-03-123
-
NoteResearch use only, not for human use.
-
Brief DescriptionBSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
-
DescriptionBSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
-
In VitroBSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis.
-
In Vivo——
-
Synonyms——
-
PathwayPROTACs
-
TargetPROTAC
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2361493-16-3
-
Formula Weight937.01
-
Molecular FormulaC??H??N??O??
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (106.72 mM)
-
SMILESO=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9.
molnova catalog
related products
-
BETd-246
A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity.
-
Foretinib-Based PROT...
Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
-
Mal-amido-PEG4-NHS e...
Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
