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BSJ-03-123

CAS No. 2361493-16-3

BSJ-03-123( —— )

Catalog No. M21744 CAS No. 2361493-16-3

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BSJ-03-123
  • Note
    Research use only, not for human use.
  • Brief Description
    BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
  • Description
    BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
  • In Vitro
    BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2361493-16-3
  • Formula Weight
    937.01
  • Molecular Formula
    C??H??N??O??
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (106.72 mM)
  • SMILES
    O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9.
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