BSJ-03-123( —— )

Catalog No. M21744 CAS No. 2361493-16-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

BSJ-03-123
Note

Research use only, not for human use.
Brief Description

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
Description

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
In Vitro

BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis.
In Vivo

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Synonyms

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Pathway

PROTACs
Target

PROTAC
Recptor

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Research Area

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Indication

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CAS Number

2361493-16-3
Formula Weight

937.01
Molecular Formula

C??H??N??O??
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (106.72 mM)
SMILES

O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3
Chemical Name

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1. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9.

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