BRD9539

CAS No. 1374601-41-8

BRD9539( —— )

Catalog No. M20714 CAS No. 1374601-41-8

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 27 In Stock
5MG 42 In Stock
10MG 71 In Stock
25MG 119 In Stock
50MG 176 In Stock
100MG 259 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BRD9539
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.
  • Description
    BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) also known as G9a with an IC50 value of 6.3 μM.
  • In Vitro
    BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    G9a
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1374601-41-8
  • Formula Weight
    399.44
  • Molecular Formula
    C24H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35 mg/mL (87.62 mM)
  • SMILES
    OC(=O)c1ccc2n(CCCc3ccccc3)c(NC(=O)c3ccccc3)nc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yuan Y Wang Q Paulk J et al. A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma[J]. ACS Chemical Biology 2012 7(7):1152-1157.
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