Cart
sales@molnova.com
BPTES
CAS No. 314045-39-1
BPTES ( BPTES )
Catalog No. M18414 CAS No. 314045-39-1
BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 57 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 25MG | 138 | In Stock |
|
| 50MG | 206 | In Stock |
|
| 100MG | 308 | In Stock |
|
| 200MG | 447 | In Stock |
|
| 500MG | 732 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBPTES
-
NoteResearch use only, not for human use.
-
Brief DescriptionBPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
-
DescriptionBPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.
-
SynonymsBPTES
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorGlutaminase GLS1 (KGA)
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number314045-39-1
-
Formula Weight524.68
-
Molecular FormulaC24H24N6O2S3
-
Purity98%
-
SolubilityDMSO : 50 mg/mL 95.30 mM;H2O : < 0.1 mg/mL
-
SMILESO=C(Cc1ccccc1)Nc1nnc(s1)CCSCCc1sc(nn1)NC(=O)Cc1ccccc1
-
Chemical NameN,N'-((thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Le A., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21.
molnova catalog
related products
-
SRT 1720 dihydrochlo...
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
-
SRT 3025
SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein.
-
N-Caffeoyltryptophan
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
