JH-T4 ( —— )

Catalog No. M17043 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JH-T4
Note

Research use only, not for human use.
Brief Description

JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM.
Description

JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation; inhibited both the deacetylation and defatty-acylation activity of SIRT2 in vitro with IC50 of 30-50 nM; JH-T4 is the first small molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a. JH-T4 also inhibits SIRT1 and SIRT3 in vitro.
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

--
Formula Weight

597.86
Molecular Formula

C34H51N3O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC(O)=C2)=O
Chemical Name

benzyl (S)-(1-((3-hydroxyphenyl)amino)-1-oxo-6-tetradecanethioamidohexan-2-yl)carbamate

1. Spiegelman NA, et al. ChemMedChem. 2019 Feb 7. doi: 10.1002/cmdc.201800715.

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