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JH-T4
CAS No.
JH-T4 ( —— )
Catalog No. M17043 CAS No.
JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJH-T4
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NoteResearch use only, not for human use.
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Brief DescriptionJH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM.
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DescriptionJH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation; inhibited both the deacetylation and defatty-acylation activity of SIRT2 in vitro with IC50 of 30-50 nM; JH-T4 is the first small molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a. JH-T4 also inhibits SIRT1 and SIRT3 in vitro.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight597.86
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Molecular FormulaC34H51N3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC(O)=C2)=O
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Chemical Namebenzyl (S)-(1-((3-hydroxyphenyl)amino)-1-oxo-6-tetradecanethioamidohexan-2-yl)carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Spiegelman NA, et al. ChemMedChem. 2019 Feb 7. doi: 10.1002/cmdc.201800715.
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