BMS-641988
CAS No. 573738-99-5
BMS-641988 ( BMS 641988;BMS641988 )
Catalog No. M15093 CAS No. 573738-99-5
BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 1053 | Get Quote |
|
50MG | 2142 | Get Quote |
|
100MG | 2790 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameBMS-641988
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM.
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DescriptionBMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM; displays high selectivity over the glucocorticoid and progesterone receptors; displayed 3-7-fold increased antagonist activity of AR transactivation compared with bicalutamide; strongly inhibits androgen-dependent growth of the ventral prostate and seminal vesicles in rats, and is efficacious in CWR-22-BMSLD1 tumors initially refractory to treatment with bicalutamide.Prostate Cancer Phase 1 Clinical
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SynonymsBMS 641988;BMS641988
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor (AR)
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Research AreaCancer
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IndicationProstate Cancer
Chemical Information
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CAS Number573738-99-5
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Formula Weight471.45
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Molecular FormulaC20H20F3N3O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCS(=O)(N[C@H](C[C@]1(C)[C@@]23[H])[C@@](O1)(C)[C@]3([H])C(N(C4=CC=C(C#N)C(C(F)(F)F)=C4)C2=O)=O)=O
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Chemical NameN-((3aR,4R,5R,7R,7aS)-2-(4-cyano-3-(trifluoromethyl)phenyl)-4,7-dimethyl-1,3-dioxooctahydro-1H-4,7-epoxyisoindol-5-yl)ethanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Balog A, et al. ACS Med Chem Lett. 2015 Jun 19;6(8):908-12.
2. Attar RM, et al. Cancer Res. 2009 Aug 15;69(16):6522-30.
3. Rathkopf D, et al. Clin Cancer Res. 2011 Feb 15;17(4):880-7.
2. Attar RM, et al. Cancer Res. 2009 Aug 15;69(16):6522-30.
3. Rathkopf D, et al. Clin Cancer Res. 2011 Feb 15;17(4):880-7.
molnova catalog
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