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EPI-001

CAS No. 227947-06-0

EPI-001 ( EPI001 )

Catalog No. M13623 CAS No. 227947-06-0

EPI-001 is a small molecule that blocks transactivation of the androgen Receptor (AR) NTD (IC50=6 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 63 Get Quote
25MG 129 Get Quote
50MG 228 Get Quote
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Biological Information

  • Product Name
    EPI-001
  • Note
    Research use only, not for human use.
  • Brief Description
    EPI-001 is a small molecule that blocks transactivation of the androgen Receptor (AR) NTD (IC50=6 uM).
  • Description
    EPI-001 is a small molecule that blocks transactivation of the androgen Receptor (AR) NTD (IC50=6 uM) and specificly inhibits AR without attenuating transcriptional activities of related steroid receptors; targets the transactivation unit 5 of AR and interacts with AF-1 in the NTD to prevent protein-protein interactions; inhibits endogenous expression of androgen-regulated genes, inhibits both androgen-dependent and androgen-independent (OCM-induced) proliferation of LNCaP cells; reduces the growth of CRPC xenografts; also is a selective PPAR-gamma modulator.
  • Synonyms
    EPI001
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    227947-06-0
  • Formula Weight
    394.89
  • Molecular Formula
    C21H27ClO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OCC(O)COC1=CC=C(C(C)(C2=CC=C(OCC(O)CCl)C=C2)C)C=C1
  • Chemical Name
    3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Myung JK, et al. J Clin Invest. 2013 Jul;123(7):2948-60.
2. De Mol E, et al. ACS Chem Biol. 2016 Sep 16;11(9):2499-505.
3. Andersen RJ, et al. Cancer Cell. 2010 Jun 15;17(6):535-46.
4. Brand LJ, et al. Oncotarget. 2015 Feb 28;6(6):3811-24.
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