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Apogossypol

CAS No. 66389-74-0

Apogossypol ( +)-Apogossypol;NSC 736630 )

Catalog No. M15530 CAS No. 66389-74-0

Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Apogossypol
  • Note
    Research use only, not for human use.
  • Brief Description
    Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
  • Description
    Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively; induces apoptosis of tumor cell lines, inhibits the growth and proliferation of prostate cancer cells by downregulating Bcl2 protein expression and activating caspase3 and 8; displays superior activity to gossypol in terms of reducing splenomegaly and reducing B-cell counts in spleens of Bcl-2-transgenic mice.
  • Synonyms
    +)-Apogossypol;NSC 736630
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    66389-74-0
  • Formula Weight
    462.53
  • Molecular Formula
    C28H30O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(C)C)O)O)O)O)O)O)C(C)C
  • Chemical Name
    [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Becattini B, et al. Chem Biol. 2004 Mar;11(3):389-95.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15;111(6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun;11(6):4142-8.
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