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Apogossypol
CAS No. 66389-74-0
Apogossypol ( +)-Apogossypol;NSC 736630 )
Catalog No. M15530 CAS No. 66389-74-0
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameApogossypol
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NoteResearch use only, not for human use.
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Brief DescriptionApogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
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DescriptionApogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively; induces apoptosis of tumor cell lines, inhibits the growth and proliferation of prostate cancer cells by downregulating Bcl2 protein expression and activating caspase3 and 8; displays superior activity to gossypol in terms of reducing splenomegaly and reducing B-cell counts in spleens of Bcl-2-transgenic mice.
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Synonyms+)-Apogossypol;NSC 736630
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number66389-74-0
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Formula Weight462.53
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Molecular FormulaC28H30O6
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(C)C)O)O)O)O)O)O)C(C)C
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Chemical Name[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Becattini B, et al. Chem Biol. 2004 Mar;11(3):389-95.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15;111(6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun;11(6):4142-8.
2. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13.
3. Kitada S, et al. Blood. 2008 Mar 15;111(6):3211-9.
4. Zhan W, et al. Mol Med Rep. 2015 Jun;11(6):4142-8.
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