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AT-101
CAS No. 866541-93-7
AT-101 ( R)-(-)-Gossypol acetic acid;(-)-Gossypol acetic acid )
Catalog No. M16298 CAS No. 866541-93-7
A natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 203 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAT-101
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NoteResearch use only, not for human use.
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Brief DescriptionA natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
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DescriptionA natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes; a BH3 mimetic that binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins, inhibits tumor growth in Wus1-bearing mice.Blood Cancer Phase 2 Clinical
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SynonymsR)-(-)-Gossypol acetic acid;(-)-Gossypol acetic acid
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2;Bcl-xL;Mcl-1
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number866541-93-7
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Formula Weight578.61
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Molecular FormulaC32H34O10
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Purity>98% (HPLC)
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SolubilityDMSO; Methanol: 7.75 mg/mL
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SMILESCC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O.CC(=O)O
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Chemical Name[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin J, et al. Oncol Rep. 2013 Aug;30(2):731-8.
2. Ciereszko A, et al. Aquat Toxicol, 2000,49(3):181-187.
3. Ferdek PE, et al. Cell Death Dis. 2017 Mar 2;8(3):e2640.
2. Ciereszko A, et al. Aquat Toxicol, 2000,49(3):181-187.
3. Ferdek PE, et al. Cell Death Dis. 2017 Mar 2;8(3):e2640.
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