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Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - BI-749327

BI-749327

CAS No. 2361241-23-6

BI-749327 ( —— )

Catalog No. M24070 CAS No. 2361241-23-6

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BI-749327
  • Note
    Research use only, not for human use.
  • Brief Description
    BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
  • Description
    BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    mouse TRPC6;human TRPC6;guinea pig TRPC6
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2361241-23-6
  • Formula Weight
    442.4
  • Molecular Formula
    C23H21F3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (70.63 mM; Need ultrasonic)
  • SMILES
    NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.
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