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BI-749327
CAS No. 2361241-23-6
BI-749327 ( —— )
Catalog No. M24070 CAS No. 2361241-23-6
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | In Stock |
|
| 10MG | 410 | In Stock |
|
| 25MG | 678 | In Stock |
|
| 50MG | 954 | In Stock |
|
| 100MG | 1287 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-749327
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NoteResearch use only, not for human use.
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Brief DescriptionBI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
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DescriptionBI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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Recptormouse TRPC6;human TRPC6;guinea pig TRPC6
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Research Area——
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Indication——
Chemical Information
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CAS Number2361241-23-6
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Formula Weight442.4
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Molecular FormulaC23H21F3N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (70.63 mM; Need ultrasonic)
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SMILESNC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.
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