BI-749327 ( —— )

Catalog No. M24070 CAS No. 2361241-23-6

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BI-749327
Note

Research use only, not for human use.
Brief Description

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
Description

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

mouse TRPC6;human TRPC6;guinea pig TRPC6
Research Area

——
Indication

——

Chemical Information

CAS Number

2361241-23-6
Formula Weight

442.4
Molecular Formula

C23H21F3N4O2
Purity

>98% (HPLC)
Solubility

DMSO:31.25 mg/mL (70.63 mM; Need ultrasonic)
SMILES

NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161.

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