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BG-45
CAS No. 926259-99-6
BG-45 ( BG45 )
Catalog No. M16637 CAS No. 926259-99-6
A potent and selective HDAC3 inhibitor with IC50 of 289 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 51 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | 551 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBG-45
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective HDAC3 inhibitor with IC50 of 289 nM.
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DescriptionA potent and selective HDAC3 inhibitor with IC50 of 289 nM; shows selectivity over HDAC1 and HDAC2; downregulates phosphorylation (Tyr705 and Ser727) of STAT3 and triggers hyperacetylation of STAT3 in MM cells; significantly enhances bortezomib-induced cytotoxicity; exhibits significant tumor growth inhibition in vivo in a murine xenograft model of human MM.
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SynonymsBG45
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC2;HDAC3;HDAC6
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number926259-99-6
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Formula Weight214.22
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Molecular FormulaC11H10N4O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 48 mg/mL
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SMILESO=C(C1=NC=CN=C1)NC2=CC=CC=C2N
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Chemical Name2-Pyrazinecarboxamide, N-(2-aminophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Minami J, et al. Leukemia. 2014 Mar;28(3):680-9.
2. Harada T, et al. Leukemia. 2017 May 11. doi: 10.1038/leu.2017.144.
2. Harada T, et al. Leukemia. 2017 May 11. doi: 10.1038/leu.2017.144.
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