Cart
sales@molnova.com
BG-45
CAS No. 926259-99-6
BG-45 ( BG45 )
Catalog No. M16637 CAS No. 926259-99-6
A potent and selective HDAC3 inhibitor with IC50 of 289 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 51 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | 551 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBG-45
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent and selective HDAC3 inhibitor with IC50 of 289 nM.
-
DescriptionA potent and selective HDAC3 inhibitor with IC50 of 289 nM; shows selectivity over HDAC1 and HDAC2; downregulates phosphorylation (Tyr705 and Ser727) of STAT3 and triggers hyperacetylation of STAT3 in MM cells; significantly enhances bortezomib-induced cytotoxicity; exhibits significant tumor growth inhibition in vivo in a murine xenograft model of human MM.
-
SynonymsBG45
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC1;HDAC2;HDAC3;HDAC6
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number926259-99-6
-
Formula Weight214.22
-
Molecular FormulaC11H10N4O
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 48 mg/mL
-
SMILESO=C(C1=NC=CN=C1)NC2=CC=CC=C2N
-
Chemical Name2-Pyrazinecarboxamide, N-(2-aminophenyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Minami J, et al. Leukemia. 2014 Mar;28(3):680-9.
2. Harada T, et al. Leukemia. 2017 May 11. doi: 10.1038/leu.2017.144.
2. Harada T, et al. Leukemia. 2017 May 11. doi: 10.1038/leu.2017.144.
molnova catalog
related products
-
Liquiritin apioside
Liquiritin Apioside is one of the main active components in Suan-Zao-Ren decoction as a treatment for insomnia.
-
Vorinostat
A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
-
Phenylethyl isothioc...
Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.
