BG-45

CAS No. 926259-99-6

BG-45 ( BG45 )

Catalog No. M16637 CAS No. 926259-99-6

A potent and selective HDAC3 inhibitor with IC50 of 289 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 32 In Stock
5MG 51 In Stock
10MG 87 In Stock
25MG 158 In Stock
50MG 267 In Stock
100MG 429 In Stock
200MG 551 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BG-45
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective HDAC3 inhibitor with IC50 of 289 nM.
  • Description
    A potent and selective HDAC3 inhibitor with IC50 of 289 nM; shows selectivity over HDAC1 and HDAC2; downregulates phosphorylation (Tyr705 and Ser727) of STAT3 and triggers hyperacetylation of STAT3 in MM cells; significantly enhances bortezomib-induced cytotoxicity; exhibits significant tumor growth inhibition in vivo in a murine xenograft model of human MM.
  • Synonyms
    BG45
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC2;HDAC3;HDAC6
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    926259-99-6
  • Formula Weight
    214.22
  • Molecular Formula
    C11H10N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 48 mg/mL
  • SMILES
    O=C(C1=NC=CN=C1)NC2=CC=CC=C2N
  • Chemical Name
    2-Pyrazinecarboxamide, N-(2-aminophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Minami J, et al. Leukemia. 2014 Mar;28(3):680-9.
2. Harada T, et al. Leukemia. 2017 May 11. doi: 10.1038/leu.2017.144.
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