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BCX-4430
CAS No. 222631-44-9
BCX-4430( BCX4430 | Galidesivir )
Catalog No. M13557 CAS No. 222631-44-9
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 448 | Get Quote |
|
| 50MG | 2295 | Get Quote |
|
| 100MG | 3681 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBCX-4430
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NoteResearch use only, not for human use.
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Brief DescriptionA viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.
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DescriptionA viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator; exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae,Orthomyxoviridae,Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).Ebola Virus Infection Phase 1 Clinical.
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In Vitro——
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In VivoAnimal Model:Female Syrian golden hamsters (hamsters infected with YF virus)Dosage:4 mg/kg of body weight Administration:I.p.; twice daily for 7 days Result:Significantly improved the survival of hamsters infected with YFV.
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SynonymsBCX4430 | Galidesivir
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PathwayMicrobiology/Virology
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TargetFilovirus
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RecptorFilovirus
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Research AreaInfection
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IndicationEbola Virus Infection
Chemical Information
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CAS Number222631-44-9
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Formula Weight301.7294
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Molecular FormulaC11H16ClN5O3
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 41 mg/mL
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SMILESC1=C(C2=C(N1)C(=NC=N2)N)C3C(C(C(N3)CO)O)O.Cl
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Chemical Name3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, hydrochloride (1:1), (2S,3S,4R,5R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Warren TK, et al. Nature. 2014 Apr 17;508(7496):402-5.
2. Julander JG, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14.
3. Julander JG, et al. Antiviral Res. 2017 Jan;137:14-22.
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