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BCTC
CAS No. 393514-24-4
BCTC ( BCTC )
Catalog No. M14354 CAS No. 393514-24-4
A highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 47 | In Stock |
|
| 10MG | 61 | In Stock |
|
| 25MG | 123 | In Stock |
|
| 50MG | 233 | In Stock |
|
| 100MG | 350 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBCTC
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
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DescriptionA highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively; shows selectivity against 63 other receptor, enzyme, transporter, and ion channel targets; orally bioavailable.Pain Preclinical
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SynonymsBCTC
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number393514-24-4
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Formula Weight372.89
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Molecular FormulaC20H25ClN4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CCN(C2=NC=CC=C2Cl)CC1)NC3=CC=C(C(C)(C)C)C=C3
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Chemical Name1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Valenzano KJ, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86.
2. Gavva NR, et al. Mol Pharmacol. 2005 Dec;68(6):1524-33.
3. Yamamoto M, et al. World J Gastroenterol. 2016 Nov 28;22(44):9752-9764.
2. Gavva NR, et al. Mol Pharmacol. 2005 Dec;68(6):1524-33.
3. Yamamoto M, et al. World J Gastroenterol. 2016 Nov 28;22(44):9752-9764.
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