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BCTC

CAS No. 393514-24-4

BCTC ( BCTC )

Catalog No. M14354 CAS No. 393514-24-4

A highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BCTC
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
  • Description
    A highly potent, selective, CNS-penetrant TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively; shows selectivity against 63 other receptor, enzyme, transporter, and ion channel targets; orally bioavailable.Pain Preclinical
  • Synonyms
    BCTC
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    393514-24-4
  • Formula Weight
    372.89
  • Molecular Formula
    C20H25ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N1CCN(C2=NC=CC=C2Cl)CC1)NC3=CC=C(C(C)(C)C)C=C3
  • Chemical Name
    1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Valenzano KJ, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86.
2. Gavva NR, et al. Mol Pharmacol. 2005 Dec;68(6):1524-33.
3. Yamamoto M, et al. World J Gastroenterol. 2016 Nov 28;22(44):9752-9764.
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