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BC-1485
CAS No. 2035085-19-7
BC-1485( BC1485 )
Catalog No. M13167 CAS No. 2035085-19-7
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBC-1485
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NoteResearch use only, not for human use.
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Brief DescriptionBC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
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DescriptionBC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models.
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In Vitro——
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In Vivo——
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SynonymsBC1485
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number2035085-19-7
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Formula Weight431.467
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Molecular FormulaC19H21N5O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(C(N3)=C2)NC3=O)=O)C=C1
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Chemical NameN-(1-(dimethylamino)-1-oxopropan-2-yl)-4-((2-oxo-2,3-dihydro-1H-benzo[d]imidazole)-5-sulfonamido)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46.
2. Lear T, et al. Cytokine. 2016 Dec;88:193-195.
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