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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - VHL-IN-15

VHL-IN-15

CAS No. 1360616-29-0

VHL-IN-15( VHL-IN 15 | VHL IN-15 | VHL-IN-15 )

Catalog No. M11483 CAS No. 1360616-29-0

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VHL-IN-15
  • Note
    Research use only, not for human use.
  • Brief Description
    VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
  • Description
    VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VHL-IN 15 | VHL IN-15 | VHL-IN-15
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1360616-29-0
  • Formula Weight
    410.43
  • Molecular Formula
    C21H22N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@H]1N(C(CC2=CC(C)=NO2)=O)C[C@H](O)C1)NCC3=CC=C(C4=CN=CO4)C=C3
  • Chemical Name
    (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Buckley DL, et al. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. 2. Van Molle I, et al. Chem Biol. 2012 Oct 26;19(10):1300-12.
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