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VHL-IN-15
CAS No. 1360616-29-0
VHL-IN-15( VHL-IN 15 | VHL IN-15 | VHL-IN-15 )
Catalog No. M11483 CAS No. 1360616-29-0
VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameVHL-IN-15
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NoteResearch use only, not for human use.
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Brief DescriptionVHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
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DescriptionVHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
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In Vitro——
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In Vivo——
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SynonymsVHL-IN 15 | VHL IN-15 | VHL-IN-15
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number1360616-29-0
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Formula Weight410.43
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Molecular FormulaC21H22N4O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C([C@H]1N(C(CC2=CC(C)=NO2)=O)C[C@H](O)C1)NCC3=CC=C(C4=CN=CO4)C=C3
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Chemical Name(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Buckley DL, et al. J Am Chem Soc. 2012 Mar 14;134(10):4465-8.
2. Van Molle I, et al. Chem Biol. 2012 Oct 26;19(10):1300-12.
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