BAY-958 ( BAY 958;BAY958;LDC526 )

Catalog No. M11342 CAS No. 1335490-39-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BAY-958
Note

Research use only, not for human use.
Brief Description

BAY-958 (BAY958, LDC526)is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1.
Description

BAY-958 (BAY958, LDC526)is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1; displays 52/82/291/>900/>900-fold selectivity compared to CDK2/1/4/6/7; exhibits good antiproliferative activity invitro, for example against HeLa cells (IC50=1000nM) and MOLM-13 cells (IC50=280nM); displays efficient cytotoxic activity against CLL cells in vitro, decreases CLL MCL-1 protein levels and triggers apoptosis rather than inhibiting proliferation; decreases splenic human CLL numbers in xenografted NSG mice, shows significant CLL cell cytotoxicity in TCL1 transgenic mice.
Synonyms

BAY 958;BAY958;LDC526
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

1335490-39-5
Formula Weight

389.41
Molecular Formula

C17H16FN5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

CS(=O)(NC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)=O
Chemical Name

(3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)phenyl)methanesulfonamide

1. Lücking U, et al. ChemMedChem. 2017 Nov 8;12(21):1776-1793.
2.Gthert JR, et al. Oncotarget. 2018 May 29;9(41):26353-26369.

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