Ibulocydine

CAS No. 1314096-68-8

Ibulocydine ( Ibulocydine )

Catalog No. M11259 CAS No. 1314096-68-8

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ibulocydine
  • Note
    Research use only, not for human use.
  • Brief Description
    Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
  • Description
    Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively; reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis; shows effectivity in HCC xenografts with no toxic side effects.
  • Synonyms
    Ibulocydine
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1314096-68-8
  • Formula Weight
    458.27
  • Molecular Formula
    C16H20BrN5O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C(OC[C@@H]1O[C@H](N2C=NC(N)=C3C2=NC(Br)=C3C(N)=O)[C@@H](O)[C@@H]1O)=O
  • Chemical Name
    ((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.
2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.
3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.
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