Ibulocydine
CAS No. 1314096-68-8
Ibulocydine ( Ibulocydine )
Catalog No. M11259 CAS No. 1314096-68-8
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 963 | Get Quote |
|
50MG | 1962 | Get Quote |
|
100MG | 2520 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameIbulocydine
-
NoteResearch use only, not for human use.
-
Brief DescriptionIbulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
-
DescriptionIbulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively; reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis; shows effectivity in HCC xenografts with no toxic side effects.
-
SynonymsIbulocydine
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1314096-68-8
-
Formula Weight458.27
-
Molecular FormulaC16H20BrN5O6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)C(OC[C@@H]1O[C@H](N2C=NC(N)=C3C2=NC(Br)=C3C(N)=O)[C@@H](O)[C@@H]1O)=O
-
Chemical Name((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.
2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.
3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.
2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.
3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.
molnova catalog
related products
-
(R)-CR8
(R)-CR8 is a potent and selective CDK inhibitor.A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor.
-
Dalpiciclib
Dalpiciclib is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4?nM and 9.9?nM, respectively.
-
CGP-74514A hydrochlo...
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.