Ibulocydine

Research use only, not for human use.

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively; reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis; shows effectivity in HCC xenografts with no toxic side effects.

Ibulocydine

Angiogenesis

CDK

CDK

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——

1314096-68-8

458.27

C16H20BrN5O6

>98% (HPLC)

——

CC(C)C(OC[C@@H]1O[C@H](N2C=NC(N)=C3C2=NC(Br)=C3C(N)=O)[C@@H](O)[C@@H]1O)=O

((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate

(-20℃)

With Ice Pack

≥ 2 years