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BAI1

CAS No. 335165-68-9

BAI1( —— )

Catalog No. M20096 CAS No. 335165-68-9

BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BAI1
  • Note
    Research use only, not for human use.
  • Brief Description
    BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
  • Description
    BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
  • In Vitro
    Apoptosis Analysis Cell Line:Mouse MEF Concentration:0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM Incubation Time:8 hours Result:Inhibited cell death in BAX-dependent manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bax
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    335165-68-9
  • Formula Weight
    467.2
  • Molecular Formula
    C19H21Br2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 15 mg/mL (32.1 mM);Water: Insoluble
  • SMILES
    OC(CN1CCNCC1)Cn1c2ccc(Br)cc2c2cc(Br)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bombrun A et al. 36-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J Med Chem. 2003 Oct 9;46(21):4365-8.
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