B591 ( B-591;B 591 )

Catalog No. M12079 CAS No. 1498412-41-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

B591
Note

Research use only, not for human use.
Brief Description

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.
Description

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively; induces a dose-dependent decrease of PIP3/PI (4,5)P2 ratio with IC50 of 1.91 uM in HCT116 cells; shows effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines; exhibited more potency in suppressing cancer stem cells (CSCs) survival and inducing CSCs apoptosis, and presence of B591 effectively eliminated paclitaxel-enriched CSCs; preferentially decreases CSCs levels in mouse xenograft model of human breast cancer.
Synonyms

B-591;B 591
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

——

CAS Number

1498412-41-1
Formula Weight

528.29
Molecular Formula

C25H24Br2N2O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3-(2-bromobenzyl)-1-((2,3-dihydrobenzofuran-5-yl)methyl)-5,6-dimethyl-1H-benzo[d]imidazol-3-ium bromide

1. Zhou H, et al. Oncogene. 2019 Jan 11. doi: 10.1038/s41388-018-0674-5.

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