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Home - Products - PI3K/Akt/mTOR signaling - PI3K - IC-87114

IC-87114

CAS No. 371242-69-2

IC-87114 ( IC87114;IC 87114 )

Catalog No. M14279 CAS No. 371242-69-2

A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IC-87114
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
  • Description
    A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM; displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ; inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis; inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation; reduces vascular permeability in a murine model of asthma.
  • Synonyms
    IC87114;IC 87114
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kβ;PI3Kγ;PI3Kδ
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    371242-69-2
  • Formula Weight
    397.43
  • Molecular Formula
    C22H19N7O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(C2=CC=CC=C2C)C(CN3C=NC4=C(N)N=CN=C34)=NC5=C1C(C)=CC=C5
  • Chemical Name
    4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sadhu C, et al. J Immunol. 2003 Mar 1;170(5):2647-54.
2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.
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