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IC-87114
CAS No. 371242-69-2
IC-87114 ( IC87114;IC 87114 )
Catalog No. M14279 CAS No. 371242-69-2
A potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
|
| 5MG | 47 | In Stock |
|
| 10MG | 75 | In Stock |
|
| 25MG | 133 | In Stock |
|
| 50MG | 227 | In Stock |
|
| 100MG | 357 | In Stock |
|
| 200MG | 524 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIC-87114
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
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DescriptionA potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM; displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ; inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis; inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation; reduces vascular permeability in a murine model of asthma.
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SynonymsIC87114;IC 87114
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number371242-69-2
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Formula Weight397.43
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Molecular FormulaC22H19N7O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(C2=CC=CC=C2C)C(CN3C=NC4=C(N)N=CN=C34)=NC5=C1C(C)=CC=C5
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Chemical Name4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sadhu C, et al. J Immunol. 2003 Mar 1;170(5):2647-54.
2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.
2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.
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