Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - Asivatrep

Asivatrep

CAS No. 1005168-10-4

Asivatrep ( PAC-14028;PAC14028 )

Catalog No. M10042 CAS No. 1005168-10-4

Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 312 Get Quote
50MG 1341 Get Quote
100MG 1791 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Asivatrep
  • Note
    Research use only, not for human use.
  • Brief Description
    Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons.
  • Description
    Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1; inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice, also attenuates dermatitis-associated barrier damages in Df and OXZ models.Dermatitis Phase 3 Clinical
  • Synonyms
    PAC-14028;PAC14028
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    Inflammation/Immunology
  • Indication
    Dermatitis

Chemical Information

  • CAS Number
    1005168-10-4
  • Formula Weight
    491.47
  • Molecular Formula
    C21H22F5N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=C(N[C@@H](C1=CC(F)=C(NS(=O)(C)=O)C(F)=C1)C)/C=C/C2=CC=C(C(F)(F)F)N=C2CCC
  • Chemical Name
    2-Propenamide, N-[(1R)-1-[3,5-difluoro-4-[(methylsulfonyl)amino]phenyl]ethyl]-3-[2-propyl-6-(trifluoromethyl)-3-pyridinyl]-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yun JW, et al. J Dermatol Sci. 2011 Apr;62(1):8-15.
2. Yun JW, et al. J Invest Dermatol. 2011 Jul;131(7):1576-9.
3. Lim KM, et al. Arch Pharm Res. 2012 Mar;35(3):393-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Linoleoyl Ethanolami...

    Linoleoyl Ethanolamide is an endocannabinoid agent.?It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

  • LASSBio-1135

    LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan.

  • GSK2193874

    GSK2193874 was identified as a selective orally active TRPV4 blocker.

Sign In Join Free