Artemether( Falcidol | Larither | Malartem | Paluther | SM-224 )

Catalog No. M15754 CAS No. 71963-77-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Artemether
Note

Research use only, not for human use.
Brief Description

Artemether is an antimalarial agent used to treat acute uncomplicated malaria.
Description

Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
In Vitro

Western Blot Analysis Cell Line:RAW264.7 cells (treated with 100?ng/mL RANKL) Concentration:10 μM Incubation Time:6 h Result:Inhibited the activation of MAPK subfamilies, including ERK, JNK, and p38.Cell Cycle Analysis Cell Line:ConA-stimulated T lymphocytes Concentration:1, 10 and 50?μM Incubation Time:72 h Result:Arrested 47, 56 and 91% (at 1, 10 and 50?μM) of the cells at G0/G1 phases, respectively.
In Vivo

Animal Model:LPS (5 mg/kg) treated mice Dosage:10 mg/kg Administration:i.p., 8 days Result:Prevented LPS induced osteolytic bone loss and the reduction in bone volume. Increased bone volume/total volume (BV/TV), decreased osteoclast surface/bone surface (Oc.S/BS) and number of TRAP-positive cells.
Synonyms

Falcidol | Larither | Malartem | Paluther | SM-224
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

71963-77-4
Formula Weight

298.38
Molecular Formula

C16H26O5
Purity

>98% (HPLC)
Solubility

Ethanol: 60 mg/mL (201.09 mM); DMSO: 60 mg/mL (201.09 mM)
SMILES

C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C
Chemical Name

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

1.Ma Y, et al. Antimicrob Agents ChemOthers. 2014 Oct;58(10):5658-65.

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