Artemether

Research use only, not for human use.

Artemether is an antimalarial agent used to treat acute uncomplicated malaria.

Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.

Western Blot Analysis Cell Line:RAW264.7 cells (treated with 100?ng/mL RANKL) Concentration:10 μM Incubation Time:6 h Result:Inhibited the activation of MAPK subfamilies, including ERK, JNK, and p38.Cell Cycle Analysis Cell Line:ConA-stimulated T lymphocytes Concentration:1, 10 and 50?μM Incubation Time:72 h Result:Arrested 47, 56 and 91% (at 1, 10 and 50?μM) of the cells at G0/G1 phases, respectively.

Animal Model:LPS (5 mg/kg) treated mice Dosage:10 mg/kg Administration:i.p., 8 days Result:Prevented LPS induced osteolytic bone loss and the reduction in bone volume. Increased bone volume/total volume (BV/TV), decreased osteoclast surface/bone surface (Oc.S/BS) and number of TRAP-positive cells.

Falcidol | Larither | Malartem | Paluther | SM-224

Others

Other Targets

Others

Infection

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71963-77-4

298.38

C16H26O5

>98% (HPLC)

Ethanol: 60 mg/mL (201.09 mM); DMSO: 60 mg/mL (201.09 mM)

C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

(-20℃)

With Ice Pack

≥ 2 years