IMD-0560

Research use only, not for human use.

IMD-0560 is a novel inhibitor of IκB kinase β.

IMD-0560 is a novel inhibitor of IκB kinase β.

Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.

The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.

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Others

Other Targets

IKKβ

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439144-66-8

428.12

C15H8BrF6NO2

>98% (HPLC)

Ethanol:50 mg/mL (116.79 mM; Need ultrasonic)

O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O

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(-20℃)

With Ice Pack

≥ 2 years