Cart
sales@molnova.com
IMD-0560
CAS No. 439144-66-8
IMD-0560( —— )
Catalog No. M24398 CAS No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 160 | In Stock |
|
| 10MG | 260 | In Stock |
|
| 25MG | 439 | In Stock |
|
| 50MG | 644 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIMD-0560
-
NoteResearch use only, not for human use.
-
Brief DescriptionIMD-0560 is a novel inhibitor of IκB kinase β.
-
DescriptionIMD-0560 is a novel inhibitor of IκB kinase β.
-
In VitroPretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
-
In VivoThe tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorIKKβ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number439144-66-8
-
Formula Weight428.12
-
Molecular FormulaC15H8BrF6NO2
-
Purity>98% (HPLC)
-
SolubilityEthanol:50 mg/mL (116.79 mM; Need ultrasonic)
-
SMILESO=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.
molnova catalog
related products
-
Sulfo-NHS-LC-Biotin ...
Sulfo-NHS-LC-Biotin sodium is an amine-reactive biotinylation reagent used for antibody labeling.
-
Potassium 1-Naphthal...
1-Naphthaleneacetate is used as a plant Growth Regulator that affects conidial germination sporulation mycelial growth cell surface morphology and the viability of certain fungal plant pathogens.
-
16-hydroxy Hexadecan...
16-hydroxy Hexadecanoic Acid (Juniperic acid) is a compound isolated from the leaves and stems of Arabidopsis thaliana and can be used to prevent, alleviate, or treat metabolic diseases.
