IMD-0560

CAS No. 439144-66-8

IMD-0560( —— )

Catalog No. M24398 CAS No. 439144-66-8

IMD-0560 is a novel inhibitor of IκB kinase β.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 160 In Stock
10MG 260 In Stock
25MG 439 In Stock
50MG 644 In Stock
100MG 888 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    IMD-0560
  • Note
    Research use only, not for human use.
  • Brief Description
    IMD-0560 is a novel inhibitor of IκB kinase β.
  • Description
    IMD-0560 is a novel inhibitor of IκB kinase β.
  • In Vitro
    Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
  • In Vivo
    The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IKKβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    439144-66-8
  • Formula Weight
    428.12
  • Molecular Formula
    C15H8BrF6NO2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol:50 mg/mL (116.79 mM; Need ultrasonic)
  • SMILES
    O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.
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