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IMD-0560

CAS No. 439144-66-8

IMD-0560( —— )

Catalog No. M24398 CAS No. 439144-66-8

IMD-0560 is a novel inhibitor of IκB kinase β.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IMD-0560
  • Note
    Research use only, not for human use.
  • Brief Description
    IMD-0560 is a novel inhibitor of IκB kinase β.
  • Description
    IMD-0560 is a novel inhibitor of IκB kinase β.
  • In Vitro
    Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
  • In Vivo
    The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IKKβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    439144-66-8
  • Formula Weight
    428.12
  • Molecular Formula
    C15H8BrF6NO2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol:50 mg/mL (116.79 mM; Need ultrasonic)
  • SMILES
    O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.
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