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Arg-AMS

CAS No. 301351-95-1

Arg-AMS( —— )

Catalog No. M32787 CAS No. 301351-95-1

Arg-AMS is an arginine tRNA synthetase inhibitor with antiviral activity that targets the host protein CD163 to inhibit porcine blue ear virus and the highly pathogenic strain HP-PRRSV, and can be used to study viral infections and myeloma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Arg-AMS
  • Note
    Research use only, not for human use.
  • Brief Description
    Arg-AMS is an arginine tRNA synthetase inhibitor with antiviral activity that targets the host protein CD163 to inhibit porcine blue ear virus and the highly pathogenic strain HP-PRRSV, and can be used to study viral infections and myeloma.
  • Description
    Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
  • In Vitro
    Arg-AMS inhibits the Orn-activating domain of GrsB with an IC50 value of 4.6 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Antiviral
  • Recptor
    Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    301351-95-1
  • Formula Weight
    502.51
  • Molecular Formula
    C16H26N10O7S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (199.00 mM) H2O : 100 mg/mL (199.00 mM; Ultrasonic)
  • SMILES
    N[C@@H](CCCNC(N)=N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kasai S, et al. Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling. Chem Commun (Camb). 2015 Nov 11;51(87):15764-7.?
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