Amenamevir ( ASP2151; ASP-2151; ASP 2151; Amenamevir )

Catalog No. M17608 CAS No. 841301-32-4

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Product Name

Amenamevir
Note

Research use only, not for human use.
Brief Description

Amenamevir is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL).
Description

Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. ASP2151 had significantly better anti-HSV activity against herpes simplex keratitis than valacyclovir and acyclovir after systemic or topical use.
Synonyms

ASP2151; ASP-2151; ASP 2151; Amenamevir
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

helicase-primase
Research Area

Infection
Indication

——

CAS Number

841301-32-4
Formula Weight

482.56
Molecular Formula

C24H26N4O5S
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL; 103.62 mM
SMILES

Cc1c(c(ccc1)C)N(CC(=O)Nc1ccc(cc1)c1nocn1)C(=O)C1CCS(=O)(=O)CC1
Chemical Name

N-(2-((4-(1,2,4-oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide

1.Katsumata K, et al.Antimicrob Agents Chemother. 2013 Mar;57(3):1339-46.

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