Voreloxin( SNS-595;Vosaroxin;AG 7352 )

Catalog No. M12652 CAS No. 175414-77-4

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
250mg	Get Quote	In stock
50mg	1087	In stock
10mg	266	In stock

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Biological Information

Product Name

Voreloxin
Note

Research use only, not for human use.
Brief Description

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.
Description

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II; exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.Chemotherapeutic Agents Phase 3 Clinical
Synonyms

SNS-595;Vosaroxin;AG 7352
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

Topo II
Research Area

Cancer
Indication

Chemotherapeutic

Chemical Information

CAS Number

175414-77-4
Formula Weight

401.44
Molecular Formula

C18H19N5O4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O
Chemical Name

1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.
2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.
3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.

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