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Home - Products - Cell Cycle/DNA Damage - Topoisomerase - Voreloxin

Voreloxin

CAS No. 175414-77-4

Voreloxin ( SNS-595;Vosaroxin;AG 7352 )

Catalog No. M12652 CAS No. 175414-77-4

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Voreloxin
  • Note
    Research use only, not for human use.
  • Brief Description
    A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.
  • Description
    A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II; exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.Chemotherapeutic Agents Phase 3 Clinical
  • Synonyms
    SNS-595;Vosaroxin;AG 7352
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topo II
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    175414-77-4
  • Formula Weight
    401.44
  • Molecular Formula
    C18H19N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O
  • Chemical Name
    1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.
2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.
3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.
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