Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Topoisomerase - Voreloxin

Voreloxin

CAS No. 175414-77-4

Voreloxin ( SNS-595;Vosaroxin;AG 7352 )

Catalog No. M12652 CAS No. 175414-77-4

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 88 Get Quote
5MG 162 Get Quote
10MG 264 Get Quote
25MG 474 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Voreloxin
  • Note
    Research use only, not for human use.
  • Brief Description
    A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.
  • Description
    A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II; exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.Chemotherapeutic Agents Phase 3 Clinical
  • Synonyms
    SNS-595;Vosaroxin;AG 7352
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topo II
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    175414-77-4
  • Formula Weight
    401.44
  • Molecular Formula
    C18H19N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O
  • Chemical Name
    1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.
2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.
3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Irinotecan Hydrochlo...

    Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.

  • Idarubicin hydrochlo...

    An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

  • 9-Aminocamptothecin

    9-Aminocamptothecin is an inhibitor of topoisomerase I with potent anticancer activity.

Sign In Join Free