Amcasertib ( BBI-503 )

Catalog No. M10454 CAS No. 1129403-56-0

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Product Name

Amcasertib
Note

Research use only, not for human use.
Brief Description

A small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases.
Description

A small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases; targets and inhibits one or more pathways involved in cancer stem cell survival, shows potential antineoplastic activity.Liver Cancer Phase 2 Clinical
Synonyms

BBI-503
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

Liver Cancer

CAS Number

1129403-56-0
Formula Weight

539.69
Molecular Formula

C31H33N5O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
Chemical Name

1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[[1,2-dihydro-2-oxo-5-(2-phenyl-4-thiazolyl)-3H-indol-3-ylidene]methyl]-2,4-dimethyl-

1. Marcucci F, et al. Front Oncol. 2016 May 10;6:115.
2. Iv Santaliz-Ruiz LE, et al. Int J Cancer. 2014 Dec 15;135(12):2741-8.

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