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GGTI 298
CAS No. 1217457-86-7
GGTI 298( —— )
Catalog No. M17885 CAS No. 1217457-86-7
GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 202 | In Stock |
|
| 5MG | 154 | In Stock |
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| 10MG | 240 | In Stock |
|
| 25MG | 466 | In Stock |
|
| 50MG | 635 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGGTI 298
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NoteResearch use only, not for human use.
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Brief DescriptionGGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
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DescriptionGGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
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In VitroRhoA inhibitor (GGTI298 Trifluoroacetate) significantly reduces cAMP agonist-stimulated apical K+ conductance. Knockdown of DR4 abolishes NF-κB activation, leading to sensitization of DR5-dependent apoptosis induced by the combination of GGTI298 Trifluoroacetate and TRAIL. GGTI298 Trifluoroacetate/TRAIL activates NF-κB and inhibits Akt. Knockdown of DR5, prevents GGTI298/TRAIL-induced IκBα and p-Akt reduction, suggesting that DR5 mediates reduction of IκBα and p-Akt induced by GGTI298/TRAIL. In contrast, DR4 knockdown further facilitates GGTI298/TRAIL-induced p-Akt reduction.
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In VivoThe vivo mouse ileal loop experiments show fluid accumulation is reduced in a dose-dependent manner by TRAM-34, GGTI298 Trifluoroacetate, or H1152 when inject together with cholera toxin into the loop.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGGTase I
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number1217457-86-7
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Formula Weight593.66
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Molecular FormulaC27H33N3O3S·C2HF3O2
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Purity>98% (HPLC)
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SolubilityDMSO : 150 mg/mL 252.67 mM;
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SMILESOC(=O)C(F)(F)F.SC[C@@H](CNc1ccc(c(c1)c1cccc2c1cccc2)C(=O)N[C@H](C(=O)OC)CC(C)C)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun J, et al. J Biol Chem. 1999, 274(11):6930-4.
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