Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - Afuresertib

Afuresertib

CAS No. 1047644-62-1

Afuresertib ( GSK 2110183;GSK2110183;GSK-2110183 )

Catalog No. M10234 CAS No. 1047644-62-1

A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 41 In Stock
5MG 65 In Stock
10MG 88 In Stock
25MG 160 In Stock
50MG 259 In Stock
100MG 453 In Stock
500MG 981 In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Afuresertib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
  • Description
    A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3; also inhibits PKA (IC50=1.3 nM) and AKT1 E17K mutant (IC50=0.2 nM), selective over PKC, PKG isoforms and p70S6K; orally bioactive.Gastric Cancer Phase 1 Discontinued
  • Synonyms
    GSK 2110183;GSK2110183;GSK-2110183
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt1;Akt2;Akt3
  • Research Area
    Cancer
  • Indication
    Gastric Cancer

Chemical Information

  • CAS Number
    1047644-62-1
  • Formula Weight
    427.32
  • Molecular Formula
    C18H17Cl2FN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 40 mg/mL
  • SMILES
    CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl
  • Chemical Name
    2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dumble M, et al. PLoS One. 2014 Jun 30;9(6):e100880.
2. Spencer A, et al. Blood. 2014 Oct 2;124(14):2190-5.
3. Arceci RJ, et al. Pediatr Blood Cancer. 2017 May;64(5).
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • (E)-Akt inhibitor-IV

    (E)-Akt inhibitor-IV? ((E)-AKTIV) is an inhibitor of PI3K-Akt.

  • CYNARIN

    CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.

  • Actein

    Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients.

Sign In Join Free