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Afuresertib

CAS No. 1047644-62-1

Afuresertib ( GSK 2110183;GSK2110183;GSK-2110183 )

Catalog No. M10234 CAS No. 1047644-62-1

A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Afuresertib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
  • Description
    A potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3; also inhibits PKA (IC50=1.3 nM) and AKT1 E17K mutant (IC50=0.2 nM), selective over PKC, PKG isoforms and p70S6K; orally bioactive.Gastric Cancer Phase 1 Discontinued
  • Synonyms
    GSK 2110183;GSK2110183;GSK-2110183
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt1;Akt2;Akt3
  • Research Area
    Cancer
  • Indication
    Gastric Cancer

Chemical Information

  • CAS Number
    1047644-62-1
  • Formula Weight
    427.32
  • Molecular Formula
    C18H17Cl2FN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 40 mg/mL
  • SMILES
    CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl
  • Chemical Name
    2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dumble M, et al. PLoS One. 2014 Jun 30;9(6):e100880.
2. Spencer A, et al. Blood. 2014 Oct 2;124(14):2190-5.
3. Arceci RJ, et al. Pediatr Blood Cancer. 2017 May;64(5).
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