Akt1Akt2-IN-17 ( Akt Inhibitor 17; Akti_2008; Akti 2008; Akti2008; Akti-2008; Akt Inhibitor 17 )

Catalog No. M16440 CAS No. 893422-47-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Akt1Akt2-IN-17
Note

Research use only, not for human use.
Brief Description

A potent, selective dual Akt1 and Akt2 inhibitor with IC50 of 3.5 nM and 42 nM, respectively.
Description

A potent, selective dual Akt1 and Akt2 inhibitor with IC50 of 3.5 nM and 42 nM, respectively; shows selectivity for Akt1/2 over Akt3 (IC50=1900 nM), and highly selective over other members of the AGC family of kinases; inhibit the growth of A2780 tumors in vivo; shows good physical properties and PK profile.Lung Cancer Preclinical
Synonyms

Akt Inhibitor 17; Akti_2008; Akti 2008; Akti2008; Akti-2008; Akt Inhibitor 17
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt
Research Area

Cancer
Indication

Lung Cancer

CAS Number

893422-47-4
Formula Weight

539.63
Molecular Formula

C33H29N7O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 35 mg/mL
SMILES

O=C1C2=C(N=C(C3=CC=C(CN4CCC(C5=NNC(C6=NC=CC=C6)=N5)CC4)C=C3)C(C7=CC=CC=C7)=C2)C=CN1
Chemical Name

1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-

1. Bilodeau MT, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3178-82.
2. Li Y, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):834-6.

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