BAY-1125976

CAS No. 1402608-02-9

BAY-1125976( BAY1125976 )

Catalog No. M11680 CAS No. 1402608-02-9

A potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 42 In Stock
5MG 72 In Stock
10MG 125 In Stock
25MG 236 In Stock
50MG 417 In Stock
100MG 614 In Stock
500MG 1287 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    BAY-1125976
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.
  • Description
    A potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP; binds to active AKT1 with Kd of 2.7 nM and inactive AKT1 with Kd of 1.3 nM. displays >86-fold less potent against AKT3; inhibits the phosphorylation of AKT1 at T308 and S473 (IC50=0.9 and 1.1 nM, respectively), PRAS40 at T246 and 4EBP1 at T70; targets tumors displaying PI3K/AKT/mTOR pathway activation, inhibits cell proliferation in a broad panel of human cancer cell lines, particularly in breast and prostate cancer cell lines expressing estrogen or androgen receptors; exhibits strong in vivo patient-derived xenograft models. Solid Tumors Phase 1 Clinical
  • Synonyms
    BAY1125976
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1402608-02-9
  • Formula Weight
    383.45
  • Molecular Formula
    C23H21N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10.33 mg/mL
  • SMILES
    C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N
  • Chemical Name
    Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Politz O, et al. Int J Cancer. 2017 Jan 15;140(2):449-459.
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