BAY-1125976
CAS No. 1402608-02-9
BAY-1125976( BAY1125976 )
Catalog No. M11680 CAS No. 1402608-02-9
A potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 42 | In Stock |
|
5MG | 72 | In Stock |
|
10MG | 125 | In Stock |
|
25MG | 236 | In Stock |
|
50MG | 417 | In Stock |
|
100MG | 614 | In Stock |
|
500MG | 1287 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY-1125976
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.
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DescriptionA potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP; binds to active AKT1 with Kd of 2.7 nM and inactive AKT1 with Kd of 1.3 nM. displays >86-fold less potent against AKT3; inhibits the phosphorylation of AKT1 at T308 and S473 (IC50=0.9 and 1.1 nM, respectively), PRAS40 at T246 and 4EBP1 at T70; targets tumors displaying PI3K/AKT/mTOR pathway activation, inhibits cell proliferation in a broad panel of human cancer cell lines, particularly in breast and prostate cancer cell lines expressing estrogen or androgen receptors; exhibits strong in vivo patient-derived xenograft models. Solid Tumors Phase 1 Clinical
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SynonymsBAY1125976
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1402608-02-9
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Formula Weight383.45
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Molecular FormulaC23H21N5O
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Purity>98% (HPLC)
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SolubilityDMSO: 10.33 mg/mL
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SMILESC1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N
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Chemical NameImidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Politz O, et al. Int J Cancer. 2017 Jan 15;140(2):449-459.
molnova catalog
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