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Aftin-4

CAS No. 866893-90-5

Aftin-4( Aftin-4 | Aftin 4 | Aftin4 )

Catalog No. M17629 CAS No. 866893-90-5

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 110 In Stock
10MG 177 In Stock
25MG 357 In Stock
50MG 530 In Stock
100MG 759 In Stock
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Biological Information

  • Product Name
    Aftin-4
  • Note
    Research use only, not for human use.
  • Brief Description
    Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.
  • Description
    Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
  • In Vitro
    Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM.
  • In Vivo
    Aftin-4 increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40 or Aβ1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42 content, up to +216% at the highest dose tested.
  • Synonyms
    Aftin-4 | Aftin 4 | Aftin4
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    γ secretase(Aβ42)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    866893-90-5
  • Formula Weight
    368.48
  • Molecular Formula
    C20H28N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 250 mg/mL; 678.46 mM
  • SMILES
    CC[C@H](CO)Nc2nc1c(ncn1C(C)C)c(n2)N(C)Cc3ccccc3
  • Chemical Name
    (R)-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bettayeb K, etal. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology, 2012, 26(12):5115-23.
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