Aftin-4

Research use only, not for human use.

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

Aftin-4; Aftin 4; Aftin4

Others

Other Targets

γ secretase(Aβ42)

Neurological Disease

——

866893-90-5

368.48

C20H28N6O

98%

DMSO : ≥ 250 mg/mL; 678.46 mM

CC[C@H](CO)Nc2nc1c(ncn1C(C)C)c(n2)N(C)Cc3ccccc3

(R)-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol

(-20℃)

With Ice Pack

≥ 2 years