Adarotene
CAS No. 496868-77-0
Adarotene ( ST1926 )
Catalog No. M26599 CAS No. 496868-77-0
Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 41 | Get Quote |
|
5MG | 67 | Get Quote |
|
10MG | 120 | Get Quote |
|
25MG | 230 | Get Quote |
|
50MG | 370 | Get Quote |
|
100MG | 537 | Get Quote |
|
500MG | 1152 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameAdarotene
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NoteResearch use only, not for human use.
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Brief DescriptionAdarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.
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DescriptionAdarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.(In Vitro):Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM . Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium .(In Vivo):Adarotene (30, 40 mg/kg, p.o.) results in a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity . Adarotene (15, 20 mg/kg, p.o.) causes a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in human melanoma, MeWo, growing in nude mice .
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SynonymsST1926
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PathwayApoptosis
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TargetApoptosis
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RecptorAntibiotic; Bacterial; Fungal; Parasite; Phosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number496868-77-0
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Formula Weight374.5
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Molecular FormulaC25H26O3
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.
molnova catalog
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