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Home - Products - Endocrinology/Hormones - Opioid Receptor - Ac-RYYRIK-NH2

Ac-RYYRIK-NH2

CAS No. 200959-48-4

Ac-RYYRIK-NH2( —— )

Catalog No. M30821 CAS No. 200959-48-4

High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ac-RYYRIK-NH2
  • Note
    Research use only, not for human use.
  • Brief Description
    High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.
  • Description
    High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.
  • In Vitro
    ——
  • In Vivo
    Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    200959-48-4
  • Formula Weight
    939.12
  • Molecular Formula
    C44H70N14O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Berger et al (1999) Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 126 555 PMID:
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