
AZD-9574
CAS No. 2756333-39-6
AZD-9574( —— )
Catalog No. M28886 CAS No. 2756333-39-6
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 295 | In Stock |
![]() ![]() |
10MG | 475 | In Stock |
![]() ![]() |
25MG | 773 | In Stock |
![]() ![]() |
50MG | 1071 | In Stock |
![]() ![]() |
100MG | 1422 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameAZD-9574
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
-
DescriptionAZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.(In Vitro):AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6.(In Vivo):In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetPARP
-
RecptorAntifection
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2756333-39-6
-
Formula Weight428.44
-
Molecular FormulaC21H22F2N6O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 22.22 mg/mL (51.86 mM)
-
SMILESO=C(NC)C1=NC(F)=C(C=C1)N2CCN(CC=3C=CC=4N=C(C(=O)NC4C3F)C)CC2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hu K, Yao X. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytother Res. 2003 Jun;17(6):620-6.
molnova catalog



related products
-
E7016
E7016 (GPI 21016) is an orally available PARP inhibitor that inhibits DNA repair and enhances tumor cell radiosensitivity both in vitro and in vivo.
-
Rucaparib Camsylate
Rucaparib Camsylate is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. Rucaparib is the most effective PARP inhibitor in enzyme assays (Ki: 1.4 nM). Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilized D283Med cells.
-
Amelparib hydrochlor...
Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.