AZD-9574

CAS No. 2756333-39-6

AZD-9574( —— )

Catalog No. M28886 CAS No. 2756333-39-6

AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 295 In Stock
10MG 475 In Stock
25MG 773 In Stock
50MG 1071 In Stock
100MG 1422 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AZD-9574
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
  • Description
    AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.(In Vitro):AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6.(In Vivo):In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    Antifection
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2756333-39-6
  • Formula Weight
    428.44
  • Molecular Formula
    C21H22F2N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 22.22 mg/mL (51.86 mM)
  • SMILES
    O=C(NC)C1=NC(F)=C(C=C1)N2CCN(CC=3C=CC=4N=C(C(=O)NC4C3F)C)CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hu K, Yao X. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytother Res. 2003 Jun;17(6):620-6.
molnova catalog
related products
  • RBN-2397

    RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells.

  • OUL35

    OUL35 is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.

  • Pamiparib

    Pamiparib (BGB-290, BGB290) is a?highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity.