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Home - Products - Cell Cycle/DNA Damage - PARP - AZD-9574

AZD-9574

CAS No. 2756333-39-6

AZD-9574( —— )

Catalog No. M28886 CAS No. 2756333-39-6

AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-9574
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
  • Description
    AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.(In Vitro):AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6.(In Vivo):In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    Antifection
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2756333-39-6
  • Formula Weight
    428.44
  • Molecular Formula
    C21H22F2N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 22.22 mg/mL (51.86 mM)
  • SMILES
    O=C(NC)C1=NC(F)=C(C=C1)N2CCN(CC=3C=CC=4N=C(C(=O)NC4C3F)C)CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hu K, Yao X. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytother Res. 2003 Jun;17(6):620-6.
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