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5-amino-1,2-dihydroisoquinolin-1-one

CAS No. 93117-08-9

5-amino-1,2-dihydroisoquinolin-1-one( —— )

Catalog No. M28409 CAS No. 93117-08-9

5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 43 Get Quote
50MG 69 Get Quote
100MG 113 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    5-amino-1,2-dihydroisoquinolin-1-one
  • Note
    Research use only, not for human use.
  • Brief Description
    5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
  • Description
    5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
  • In Vitro
    5-AIQ (5000 μg) significantly reduces the number of colonies of TA 98 without metabolic activation, and TA 98 and TA 1537 with metabolic activation.
  • In Vivo
    5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test.5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver. Animal Model:Male mice Dosage:150 and 250 mg/kg Administration:Oral administration; 150 and 250 mg/kg; once Result:Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.Animal Model:Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) Dosage:3 mg/kg Administration:Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemiaResult:Reduced PARP activation and showed less staining for ICAM-1.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    TRPV1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    93117-08-9
  • Formula Weight
    160.176
  • Molecular Formula
    C9H8N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (624.34 mM)
  • SMILES
    Nc1cccc2c(O)nccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Giovanni Appendino, et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther. 2005 Feb;312(2):561-70.
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