
5-amino-1,2-dihydroisoquinolin-1-one
CAS No. 93117-08-9
5-amino-1,2-dihydroisoquinolin-1-one( —— )
Catalog No. M28409 CAS No. 93117-08-9
5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
25MG | 43 | Get Quote |
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50MG | 69 | Get Quote |
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100MG | 113 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product Name5-amino-1,2-dihydroisoquinolin-1-one
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NoteResearch use only, not for human use.
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Brief Description5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
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Description5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
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In Vitro5-AIQ (5000 μg) significantly reduces the number of colonies of TA 98 without metabolic activation, and TA 98 and TA 1537 with metabolic activation.
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In Vivo5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test.5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver. Animal Model:Male mice Dosage:150 and 250 mg/kg Administration:Oral administration; 150 and 250 mg/kg; once Result:Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.Animal Model:Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) Dosage:3 mg/kg Administration:Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemiaResult:Reduced PARP activation and showed less staining for ICAM-1.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorTRPV1
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Research Area——
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Indication——
Chemical Information
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CAS Number93117-08-9
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Formula Weight160.176
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Molecular FormulaC9H8N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (624.34 mM)
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SMILESNc1cccc2c(O)nccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Giovanni Appendino, et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther. 2005 Feb;312(2):561-70.
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