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RBN-3143
CAS No. 2360853-16-1
RBN-3143( —— )
Catalog No. M36022 CAS No. 2360853-16-1
RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 132 | In Stock |
|
| 5MG | 202 | In Stock |
|
| 10MG | 297 | In Stock |
|
| 25MG | 490 | In Stock |
|
| 50MG | 707 | In Stock |
|
| 100MG | 972 | In Stock |
|
| 500MG | 1944 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRBN-3143
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NoteResearch use only, not for human use.
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Brief DescriptionRBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
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DescriptionRBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.
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In Vitro——
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In VivoAnimal Model:Mouse of asthma models Dosage:5 ug Administration:Intranasal administration Result:Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research Area——
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Indication——
Chemical Information
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CAS Number2360853-16-1
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Formula Weight449.54
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Molecular FormulaC22H28FN3O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (55.61 mM; Ultrasonic (<60°C)
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SMILESCC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal?2022?60:?4642.
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