AZD-9567

CAS No. 1893415-00-3

AZD-9567( AZD9567 )

Catalog No. M12972 CAS No. 1893415-00-3

AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 484 Get Quote
10MG 699 Get Quote
25MG 1062 Get Quote
50MG 1431 Get Quote
100MG 1917 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AZD-9567
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.
  • Description
    AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.Rheumatoid Arthritis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation. Animal Model:Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW.Dosage:15 mg/kg/day.Administration:Oral gavage daily for 8 days.Result:Inhibited ankle swelling in the rat SCW model.
  • Synonyms
    AZD9567
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    GR
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    1893415-00-3
  • Formula Weight
    494.533
  • Molecular Formula
    C27H28F2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(F)(F)C(N[C@@H](C(C)C)[C@H](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)=O
  • Chemical Name
    2,2-Difluoro-N-[(1R,2S)-3-methyl-1-[[1-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-5-yl]oxy]-1-phenylbutan-2-yl]propanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ripa L, et al. J Med Chem. 2018 Mar 8;61(5):1785-1799.
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