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JTP-117968

CAS No. ——

JTP-117968( JTP117968 )

Catalog No. M17016 CAS No. ——

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JTP-117968
  • Note
    Research use only, not for human use.
  • Brief Description
    JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
  • Description
    JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM; shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors; exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JTP117968
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    GR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    520.596
  • Molecular Formula
    C31H31F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (4b'S,7'R,8a'S)-4b'-benzyl-7'-hydroxy-N-(2-methylpyridin-3-yl)-7'-(trifluoromethyl)-4b',6',7',8',8a',10'-hexahydro-5'H-spiro[cyclopropane-1,9'-phenanthrene]-2'-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.
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