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JTP-117968
CAS No. ——
JTP-117968( JTP117968 )
Catalog No. M17016 CAS No. ——
JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJTP-117968
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NoteResearch use only, not for human use.
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Brief DescriptionJTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
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DescriptionJTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM; shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors; exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.
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In Vitro——
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In Vivo——
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SynonymsJTP117968
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PathwayEndocrinology/Hormones
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TargetGR
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RecptorGR
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight520.596
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Molecular FormulaC31H31F3N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4b'S,7'R,8a'S)-4b'-benzyl-7'-hydroxy-N-(2-methylpyridin-3-yl)-7'-(trifluoromethyl)-4b',6',7',8',8a',10'-hexahydro-5'H-spiro[cyclopropane-1,9'-phenanthrene]-2'-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.
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