JTP-117968( JTP117968 )

Catalog No. M17016 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JTP-117968
Note

Research use only, not for human use.
Brief Description

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
Description

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM; shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors; exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.
In Vitro

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In Vivo

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Synonyms

JTP117968
Pathway

Endocrinology/Hormones
Target

GR
Recptor

GR
Research Area

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Indication

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CAS Number

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Formula Weight

520.596
Molecular Formula

C31H31F3N2O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(4b'S,7'R,8a'S)-4b'-benzyl-7'-hydroxy-N-(2-methylpyridin-3-yl)-7'-(trifluoromethyl)-4b',6',7',8',8a',10'-hexahydro-5'H-spiro[cyclopropane-1,9'-phenanthrene]-2'-carboxamide

1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.

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