Eplerenone

CAS No. 107724-20-9

Eplerenone( CGP 30083 | (+)-Eplerenone | Epoxymexrenone | SC-6110 | SC-66110 )

Catalog No. M10311 CAS No. 107724-20-9

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 57 In Stock
25MG 114 In Stock
50MG 174 In Stock
100MG 246 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Eplerenone
  • Note
    Research use only, not for human use.
  • Brief Description
    Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone.
  • Description
    Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors. (In Vitro):Eplerenone inhibits the human mineralocorticoid receptor with IC50 value of 0.081 μM.(In Vivo):Eplerenone (oral, 200 mg/kg/day for 3 months) significantly reduces oxidative stress and atherosclerosis progression in atherosclerotic apolipoprotein edeficient (EO) mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CGP 30083 | (+)-Eplerenone | Epoxymexrenone | SC-6110 | SC-66110
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    Mineralocorticoid Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    107724-20-9
  • Formula Weight
    414.49
  • Molecular Formula
    C24H30O6
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)
  • SMILES
    C[C@]12CCC(C=C1C[C@@H](C(OC)=O)[C@@H]3[C@]24[C@@H](C[C@@]5(C)[C@H]3CC[C@@]56CCC(O6)=O)O4)=O
  • Chemical Name
    methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Keidar S, et al. J Cardiovasc Pharmacol, 2003, 41(6), 955-963.
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